Rock1 CLIA Kit for Mouse(Mus musculus) | EIAab.comRock1 CLIA Kit for Mouse(Mus musculus)

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Rock1 (Gene name),

Rho-associated protein kinase 1 (Protein name ), ROCK1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Rock1;

Protein name:

Rho-associated protein kinase 1;

Alternative:

Rho-associated, coiled-coil-containing protein kinase I(ROCK-I);Rho-associated, coiled-coil-containing protein kinase 1;p160 ROCK-1(p160ROCK);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1 and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner (By similarity). Interacts with PTEN.

Function:

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. Promotes keratinocyte terminal differentiation (By similarity). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles.

Subcellular Location:

Cytoplasm Cytoplasm cytoskeleton centrosome centriole Golgi apparatus membrane Peripheral membrane protein Cell projection bleb Associated with the mother centriole and an intercentriolar linker. A small proportion is associated with Golgi membranes.

Protein Attributes:

Sequence length:

1354

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1350:

1354:

GKTS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P70335

KEGG:

mmu:19877

String:

P70335

UniGene:

Mm.6710

Pfam:

PF02185

Uniprot:

P70335

FOR

ELISA Kit for Mouse Rho-associated protein kinase 1

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E15189h

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96T

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ELISA Kit for Mouse Rho-associated protein kinase 1

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E15189r

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96T

ELISA Kit for Mouse Rho-associated protein kinase 1

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ELISA Kit for Mouse Rho-associated protein kinase 1

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E15189m

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ELISA Kit for Mouse Rho-associated protein kinase 1

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E15189b

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96T

CLIA Kit for Mouse Rho-associated protein kinase 1

Cat.:

U15189r

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96T

CLIA Kit for Mouse Rho-associated protein kinase 1

Cat.:

U15189h

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96T

CLIA Kit for Mouse Rho-associated protein kinase 1

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CLIA Kit for Mouse Rho-associated protein kinase 1

Cat.:

U15189b

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96T

CLIA Kit for Mouse Rho-associated protein kinase 1

Cat.:

U15189m

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96T

Polyclonal Antibody for Mouse Rho-associated protein kinase 1

Cat.:

P15189Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Rho-associated protein kinase 1

Cat.:

P15189Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Rho-associated protein kinase 1

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P15189Rb-r

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Polyclonal Antibody for Mouse Rho-associated protein kinase 1

Monoclonal Antibody for Mouse Rho-associated protein kinase 1

Protein for Mouse Rho-associated protein kinase 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice."
Nakagawa O. , Fujisawa K. , Ishizaki T. , Saito Y. , Nakao K. , Narumiya S.
FEBS Lett.392:189-193(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Embryo.
tissue: Heart.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-506 (ISOFORM 2)
strain: FVB/N.
tissue: Mammary gland.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 472-1354
strain: C57BL/6J.
tissue: Heart.
tissue: Liver.
4.

"ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles."
Shimizu Y. , Thumkeo D. , Keel J. , Ishizaki T. , Oshima H. , Oshima M. , Noda Y. , Matsumura F. , Taketo M.M. , Narumiya S.
J. Cell Biol.168:941-953(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
5.

"Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane."
Stroeken P.J. , Alvarez B. , Van Rheenen J. , Wijnands Y.M. , Geerts D. , Jalink K. , Roos E.
J. Cell. Physiol.208:620-628(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGB1BP1;SUBCELLULAR LOCATION
6.

"Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions."
Alvarez B. , Stroeken P.J. , Edel M.J. , Roos E.
J. Cell. Physiol.214:474-482(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGB1BP1
7.

"Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage."
Ongusaha P.P. , Qi H.H. , Raj L. , Kim Y.B. , Aaronson S.A. , Davis R.J. , Shi Y. , Liao J.K. , Lee S.W.
Sci. Signal.1:RA14-RA14(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis."
Kroll J. , Epting D. , Kern K. , Dietz C.T. , Feng Y. , Hammes H.P. , Wieland T. , Augustin H.G.
Am. J. Physiol.296:H893-H899(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability."
Vemula S. , Shi J. , Hanneman P. , Wei L. , Kapur R.
Blood115:1785-1796(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PTEN
10.

"Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."
Brunner M. , Millon-Fremillon A. , Chevalier G. , Nakchbandi I.A. , Mosher D. , Block M.R. , Albiges-Rizo C. , Bouvard D.
J. Cell Biol.194:307-322(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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